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However, stability and recrystallization of amorphous drug formulations can represent key challenges in drug solubility enhancement. In addition to hot melt extrusion and spray drying, our polymers also have a strong track record of performance for use with other technologies utilized with amorphous formulations including micro-precipitated bulk powders and fusion-based processes. In addition to solid dispersions, Evonik also has strong core competencies in other key areas to address poor drug solubility and low permeability, including particle engineering and silica technologies, and the development of formulations that enable rapid disintegration.

We offer a superior range of drug particle engineering solutions including various crystal engineering methods and dry milling capabilities that can increase surface area, alter crystalline structure, or stabilize the amorphous state. To optimize bioavailability, enable higher drug loadings, improve stability and minimize development costs, it is of paramount importance to select the right processes and functional excipients at early development stages. Such systems can help to predict the best lead carrier excipient and process parameters for you to commence initial trials.

Photonics & Lasers in Medicine

Next Article. Kongressbericht Towards the enhancement of transdermal drug delivery through thermocavitation Verbesserung der transdermalen Wirkstoffverabreichung durch Thermokavitation. Juan P. Abstract Background and objective: Although for some highly lipophillic drugs the principal barrier to permeate the human skin may reside in the essentially viable epidermal membrane, for most molecules, the stratum corneum SC is the rate-limiting barrier to drug delivery.

Zusammenfassung Hintergrund und Zielsetzung: Das Eindringen einiger lipophiler Wirkstoffe in die menschliche Haut wird durch die epidermale Membran begrenzt. Received : Revised : Accepted : Published Online : Published in Print : Citing Articles Here you can find all Crossref-listed publications in which this article is cited. Controllable direction of liquid jets generated by thermocavitation within a droplet. Padilla-Martinez, J. Ramirez-San-Juan, C.

Current Strategies for Brain Drug Delivery

Berrospe-Rodriguez, N. Korneev, G. Aguilar, P. Please enable JavaScript to access the full features of the site or access our non-JavaScript page. Issue 44, Previous Article Next Article. From the journal: Journal of Materials Chemistry B. Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures. This article is part of the themed collection: Recent Review Articles.

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Cited by. Back to tab navigation Download options Please wait Article type: Review Article. DOI: Download Citation: J.

Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures R. Jijie, A. Barras, R.

Enhancement in Drug Delivery

Boukherroub and S. Szunerits, J. Search articles by author Roxana Jijie. Alexandre Barras. Rabah Boukherroub.